Regional citrate-calcium anticoagulation during polymyxin-B hemoperfusion: A case series
نویسندگان
چکیده
منابع مشابه
Polymyxin B hemoperfusion: a mechanistic perspective
Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridge (PMX-DHP) is an established strategy in the treatment of septic shock in Japan and parts of Western Europe. PMX-DHP is currently the subject of a pivotal North American randomized controlled trial (EUPHRATES) in patients with septic shock and confirmed endotoxemia, as measured by the endotoxin activity assay. The major me...
متن کاملCitrate pharmacokinetics and calcium levels during high-flux dialysis with regional citrate anticoagulation
BACKGROUND Regional citrate anticoagulation is a very effective anticoagulation method for haemodialysis. However, it is not widely used, primarily due to the risk of hypocalcaemia. We studied citrate and calcium kinetics to better understand safety aspects of this anticoagulation method. METHODS During 15 haemodialysis treatments with a calcium-free dialysis solution, citrate was infused pre...
متن کاملIonized calcium measurements during regional citrate anticoagulation in CRRT: we need better blood gas analyzers.
Schwarzer et al. [1] showed discrepant postfilter ionized calcium concentrations [iCa] when using different blood gas analyzers (BGAs) and called for a change of the Fresenius regional citrate anticoagulation (RCA) protocol to ensure patient safety. Of note, precision of the BGAs was not tested. In our opinion, the key message of their study is that commercially available BGAs are not accurate ...
متن کاملPolymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inac...
متن کاملRegional citrate anticoagulation for continuous renal replacement therapy without post-filter monitoring of ionized calcium
*Corresponding author: Tibor Fülöp, M.D., FACP, FASN, Division of Nephrology, University of Mississippi Medical Center, 2500 North State Street, L 504; Jackson, Mississippi 39216-4505. Present address of corresponding author: Department of Medicine Division of Nephrology, Medical University of South Carolina, Charleston, USA, Email: [email protected] http://journalrip.com DOI: 10.1517...
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ژورنال
عنوان ژورنال: The International Journal of Artificial Organs
سال: 2018
ISSN: 0391-3988,1724-6040
DOI: 10.1177/0391398818762360